Table 1.

Overview of spontaneous or induced mouse models showing motor neuron degeneration.

Name	Mutated gene	Gene product	Inheritance	Human disease	Reference
Wobbler	VPS54	Subunit of the GARP complex	recessive	NA	[19]
Nmd	IGHMBP2	Immunoglobulin μ-binding protein 2	recessive	SMARD1	[20]
Pmn	TBCE	tubulin-specific chaperone E	recessive	motor neuropathy HRD/SSS	[21]
Loa	DYNC1H1	dynactin	dominant	sensory neuropathy	[22]
Cra	DYNC1H1	dynactin	dominant	sensory neuropathy	[23]

SMARD: spinal muscular atrophy with respiratory distress, HRD: hypoparathyroidism-retardation dysmorphism syndrome, SSS: Sanjad-Sakati syndrome, and NA: not available.