Figure 4.

Computer simulations show that polarized tension is sufficient to orient cell divisions and tissue growth. See Supplemental Movies S2–S4. For detailed parameter explorations, see Supplemental Figures S6 and S7. (A) Isometric tension at junctions leads to isometric clone shapes. (B) Polarized tension at junctions orients most cell divisions in the P–D axis, producing clone shapes and P–D orientation similar to in vivo clones. (C) Isometric tension with cell divisions forcibly oriented in the P–D axis produces clone shapes that are more elongated and P–D-aligned than in vivo clones. (D) Quantification of simulated clone shapes compared with wild-type in vivo clones.