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Schematic presentation of the S/preS1/preS2 gene, RNA transcripts, and translational products. Opening reading frame S has three internal AUG codons. Transcription to produce the 2.1 kb and 2.4 kb mRNAs first occurs after translation into small hepatitis B surface proteins (SHBs), middle hepatitis B surface proteins (MHBs), and large hepatitis B surface proteins (LHBs) ensues with different promoters.
