Table 2.
Mutations in viral polymerase gene induced by oral antiviral agents and corresponding changes in hepatitis B surface antigen
| Polymerase domain | Mutation in polymerase | Oral antiviral agents | Corresponding change in HBsAg |
| B | rtI169T | ETV | sF161H/L |
| rtL180M | LAM, LdT | No change | |
| rtA181T | ADV, TFV, LAM, LdT | sW1721 | |
| rtA181T | ADV, TFV, LAM, LdT | sW172L | |
| rtA181V | ADV, TFV, LdT | sL173F | |
| rtT184A | ETV | No change | |
| rtT184C | ETV | sL175F + sL176V | |
| rtT184I | ETV | No change | |
| rtT184G | ETV | sL176V | |
| rtT184S | ETV | sL175F | |
| rtT184M | ETV | sL1761 | |
| rtT184L | ETV | sL175F | |
| C | rtS202C | ETV | No change/sS193F |
| rtS202I | ETV | sV194F/S | |
| rtS202G | ETV | No change/sS193L | |
| rtM204V | LAM | sI195M | |
| rtM204I | LAM, LdT | sW1961/S/L | |
| D | rtN236T | ADV, TFV | After end of HBsAg |
| E | rtM250I | ETV | After end of HBsAg |
| rtM250V | ETV | After end of HBsAg |
1
Stop codon. Modified from reference[50]. HBsAg: Hepatitis B surface antigen; ETV: Entecavir; LAM: Lamivudine; LdT: Telbivudine; ADV: Adefovir; TFV: Tenofovir.