Table 1.
Effect of bile duct ligation and cobalt protoporphyrin or zinc protoporphyrin IX treatment on serum and urine levels of creatinine and sodium, and creatinine clearance rate (mean ± SD, n = 8-10 per group)
| Sham group | Cirrhosis group | CoPP group | ZnPP group | |
| Serum Cre (μmol/L) | 30.4 ± 1.81 | 36.3 ± 6.27a | 33.5 ± 5.98 | 45.3 ± 8.92c |
| Urine Cre (μmol/L) | 7.18 ± 1.15 | 8.08 ± 2.50 | 4.49 ± 1.51 | 6.31 ± 1.20 |
| Serum sodium (mmol/L) | 142.86 ± 3.44 | 138.75 ± 0.96a | 142.64 ± 5.43c | 136.57 ± 1.40c |
| Urine sodium (mmol/L) | 91.50 ± 12.12 | 71.33 ± 10.07a | 109.15 ± 64.93 | 66.25 ± 11.8 |
| Ccr (mL/min) | 0.23 ± 0.02 | 0.12 ± 0.05a | 0.14 ± 0.04 | 0.07 ± 0.01c |
| AST (IU/L) | 156.8 ± 18.28 | 237.2 ± 95.13a | 467.14 ± 222.28c | 209.11 ± 65.77 |
a
P < 0.05 vs sham group;
c
P < 0.05 vs cirrhotic group. CoPP: Cobalt protoporphyrin; ZnPP: Zinc protoporphyrin IX; Cre: Creatinine; Ccr: Creatinine clearance rate; AST: Aspartate aminotransferase.