Table 2.
Lumbar spine | Baseline | First year | Second year | Third year | ||||
Group A calcium/vitamin D | n (%) | 32 | 27 (84.4) | 22 (68.6) | 14 (43.8) | |||
T-score | -1.57 ± 0.31 | -1.32 ± 0.42b | -1.21 ± 0.49b | -1.18 ± 0.36b | ||||
Δ T-score (95% CI) | +0.28 ± 0.35 (0.162–0.460) | +0.33 ± 0.49 (0.109-0.558) | +0.43 ± 0.47 (0.147–0.708) | |||||
BMD | 0.90 ± 0.04 | 0.92 ± 0.05 | 0.94 ± 0.05 | 0.94 ± 0.04 | ||||
Group B + sodium fluoride | n (%) | 62 | 47 (75.8) | 36 (58.0) | 30 (48.4) | |||
T-score | -1.82 ± 0.75h | -1.60 ± 0.84d | -1.40 ± 1.01d | -1.37 ± 0.95d | ||||
Δ T-score (95% CI) | +0.22 ± 0.33 (0.125–0.321) | +0.47 ± 0.60 (0.262–0.676) | +0.51 ± 0.44 (0.338–0.682) | |||||
BMD | 0.87 ± 0.08 | 0.88 ± 0.09 | 0.90 ± 0.11 | 0.91 ± 0.11 | ||||
Group C + ibandronate | n (%) | 54 | 49 (90.1) | 34 (63.0) | 27 (50) | |||
T-score | -1.89 ± 0.71 | -1.69 ± 0.78e | -1.61 ± 0.83e | -1.56 ± 0.78f | ||||
Δ T-score (95% CI) | +0.22 ± 0.38 (0.111– 0.329) | +0.36 ± 0.53 (0.147–0.578) | +0.41 ± 0.48 (0.238–0.576) | |||||
BMD | 0.85 ± 0.08 | 0.87 ± 0.08 | 0.89 ± 0.08 | 0.90 ± 0.08 | ||||
Total | n (%) | 148 | 123 (83.1) | 92 (62.2) | 71 (47.8) |
In-treatment group change, baseline to first, second and third year: Group A, bP < 0.01; group B, dP < 0.01; group C, eP < 0.025, fP < 0.01; Between-treatment groups: hP < 0.01, group A vs group C. BMD: Bone mineral density.