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. Author manuscript; available in PMC: 2011 Jan 18.
Published in final edited form as: Curr Pharm Biotechnol. 2008 Feb;9(1):9–15. doi: 10.2174/138920108783497668

Figure 3. Proposed LpxC mechanisms.

Figure 3

Panel A. The LpxC catalytic mechanism proposed by McClerren and coworkers (2005). This proposal suggests that E78 abstracts a proton from zinc-bound water, thereby activating the water for attack on the carbonyl carbon. The proposal presented here suggests that H265 stabilizes the oxyanion intermediate, and E78 later donates a proton to the terminal amine. Panel B. An alternate hypothesis by Hernick and coworkers (2005) suggests that T191 stabilizes the oxyanion intermediate and H265 donates a proton to the liberated amine.