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Figure 6 shows a model of intracellular signaling involved in myogenic tone of coronary arteriole including EGFR tyrosine kinase, GRB2/SOS and the complex ERK1/2-JAK-STAT3. Interestingly, the complex Akt-JAK-STAT3 formation under EGFR tyrosine kinase activation is not involved in coronary arteriolar myogenic tone. These data were obtained from pressurized coronary arterioles and cultured SMC isolated from coronary arterioles.
