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. 2008 Mar 17;3:67–79.

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© 2008 The authors.

This article is published under the Creative Commons Attribution By licence. For further information go to: http://creativecommons.org/licenses/by/3.0.

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Function of GRIM-19 in steady-state. Coordinated synthesis cum assembly of mitochondrial complex-I has been well-characterized. In addition to the structural and functional proteins in complex-I, distantly-related proteins like GRIM-19 and AIF are required for proper complex-I formation. Homozygous deletion of grim19 resulted in embryonic lethality in mice which may be a result of decreased complex-I levels in the developing embryo. M-coded—mitochondrial DNA-encoded, N-coded—Nuclear DNA-encoded.