Table 1.

Antiretroviral Central Nervous System Penetration Scoring System: CNS penetration effectiveness score

Drug Class	CPE Score

	1	0.5	0

Nucleoside Reverse Transcriptase Inhibitor (NRTI)	Abacavir	Emtricitabine	Adefovir
	Zidovudine	Lamivudine	Zalcitabine
		Stavudine	Didanosine
			Tenofovir

Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)	Delavirdine	Efavirenz
Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)	Nevirapine

Protease Inhibitor (PI)^*	Amprenavir-r	Amprenavir	Nelfinavir
	Darunavir	Atazanavir	Ritonavir
	Fosamprenavir-r	Atazanavir-r	Saquinavir
	Lopinavir-r	Fosamprenavir	Saquinavir-r
	Indinavir-r	Indinavir	Tipranavir-r

Integrase Inhibitors		Elvitegravir
Integrase Inhibitors		Raltegravir

Entry Inhibitors	Vicriviroc		Enfuvirtide
Entry Inhibitors	Maraviroc		T-1249

Antiretroviral Central Nervous System (ARV CNS); CNS penetration effectiveness (CPE); Amprenavir-r: Ritonavir boosted Amprenavir; Fosamprenavir-r: Ritonavir boosted Fosamprenavir; Lopinavir-r: Ritonavir boosted Lopinavir; Indinavir-r: Ritonavir boosted Indinavir; Atazanavir-r: Ritonavir boosted Atazanavir; Saquinavir-r: Ritonavir boosted Saquinavir; Tipranavir-r: Ritonavir boosted Tipranavir