Table 4.
Univariate and multivariate linear regression estimates of the change in NPZ3 score and 95 percent confidence intervals for the association between CPE score, immunologic, virologic, additional risk factors and neurological function (NPZ3 score), where plasma HIV RNA < 50 (copies/ml) at the neurovisit (N=2636)
| Univariate*^ | Multivariate*^ | |||
|---|---|---|---|---|
| Main Variable | Change in NPZ3 score (95% CI) | P-value | Change in NPZ3 score (95% CI) | P-value |
| CPE score | ||||
| Every 1 score increase | −0.01 (−0.03,0.02) | 0.7 | ||
| CPE score (every 1 score increase) | ||||
| Among observation with ≤ 3 ARVs | −0.02 (−0.05,0.02) | 0.3 | 0.01 (−0.02,0.05) | 0.5 |
| Among observation with >3 ARVs | 0.07 (0.02,0.11) | 0.005 | 0.07 (0.02,0.12) | 0.004 |
| Confounders | ||||
| Sex | ||||
| Female vs male | −0.13 (−0.21, −0.05) | 0.002 | −0.13 (−0.22, −0.05) | 0.001 |
| Race/Ethnicity | ||||
| White vs Black | −0.11 (−0.18, −0.04) | 0.002 | −0.18 (−0.25, −0.1) | <0.001 |
| Hispanic vs Black | −0.48 (−0.56, −0.4) | <0.001 | −0.48 (−0.57, −0.4) | <0.001 |
| Age | ||||
| Every 10 year increase in age | −0.07 (−0.1, −0.03) | <0.001 | −0.09 (−0.12, −0.05) | <0.001 |
| Years of education | ||||
| Every 1 year increase | 0.03 (0.02,0.04) | <0.001 | 0.02 (0.01,0.03) | <0.001 |
| Injection drug use | ||||
| Reported vs Not reported | −0.12 (−0.22, −0.01) | 0.03 | ||
| HCV sero-status | ||||
| Ever positive vs Never or Unknown | −0.18 (−0.28, −0.09) | <0.001 | −0.15 (−0.24, −0.06) | 0.001 |
| Baseline nadir CD4 cell count (cells/ul) | ||||
| >200 vs ≤ 200 | 0.09 (0.03,0.15) | 0.003 | 0.06 (−0.01,0.13) | 0.08 |
| Baseline CD4 cell count (cells/ul) | ||||
| >200 vs ≤ 200 | 0.09 (0.03,0.16) | 0.003 | ||
| Current CD4 cell count (cells/ul) | ||||
| 351–500 vs ≤ 350 | 0.07 (0.03,0.11) | <0.001 | 0.03 (−0.01,0.06) | 0.1 |
| >500 vs ≤ 350 | 0.1 (0.06,0.14) | <0.001 | 0.04 (−0.01,0.08) | 0.09 |
| Baseline plasma HIV RNA (copies/ml) | ||||
| 10,000–100,000 vs <10,000 | −0.06 (−0.13,0.02) | 0.1 | −0.1 (−0.19, −0.01) | 0.02 |
| >100,000 vs <10,000 | −0.06 (−0.14,0.02) | 0.1 | −0.09 (−0.19,0.01) | 0.08 |
| Baseline ARV status | ||||
| ARV experienced vs ARV naive | −0.02 (−0.09,0.04) | 0.5 | −0.38 (−0.48, −0.29) | <0.001 |
| Years since first ARV use | ||||
| Every 1 year increase | 0.03 (0.03,0.04) | <0.001 | 0.05 (0.04,0.06) | <0.001 |
*
Number of ARVs in the regimen (>3 vs ≤ 3); Estimate: −0.23 (univariate), −0.16 (multivariate). These variables cannot be interpreted alone but are in the model because of the interaction.
^
Interaction term [#ARVs and CPE score]; p-value: 0.004 (univariate), 0.055 (multivariate).