Table 1.
Potential PD Biomarkers for ALK SMI Treatment in NSCLC.
| Symbol | Entrez Gene Name | Family | Fold Change | FDR Adjusted P value |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | Kinase | -3.23 | 2.48E-10 |
| ATF1 | Activating transcription factor 1 | Transcription regulator | -9.9 | 1.23E-10 |
| CCNA2 | Cyclin A2 | Other | -41.76 | 1.8E-13 |
| CCNB1 | Cyclin B1 | Other | -181.97 | 1.74E-17 |
| CCNB2 | Cyclin B2 | Other | -70.13 | 1.49E-17 |
| CCNE2 | Cyclin E2 | Other | -48.24 | 2.76E-16 |
| CDC2 | Cell division cycle 2, G1 to S and G2 to M | Kinase | -32.91 | 1.49E-17 |
| CDK2 | Cyclin-dependent kinase 2 | Kinase | -4.15 | 4.53E-12 |
| CHEK1 | CHK1 checkpoint homolog (Schizosaccharomyces pombe) | Kinase | -17.77 | 2.85E-11 |
| EGFR | Epidermal growth factor receptor | Kinase | -5.6 | 1.66E-10 |
| H2AFX | H2A histone family, member X | Other | -7.56 | 3.6E-15 |
| HMGB2 | High-mobility group box 2 | Transcription regulator | -8.3 | 2.88E-14 |
| HRAS | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | Enzyme | -3.16 | 5.04E-09 |
| IGFBP3 | Insulin-like growth factor binding protein 3 | Other | -5.71 | .00000303 |
| IL8 | Interleukin 8 | Cytokine | -8.4 | 1.97E-13 |
| IL1R1 | Interleukin 1 receptor, type I | Transmembrane receptor | -5.2 | 1.16E-11 |
| IL1RAP | Interleukin 1 receptor accessory protein | Transmembrane receptor | -18.67 | .000848 |
| IRS1 | Insulin receptor substrate 1 | Other | -6.84 | 1.84E-11 |
| KITLG | KIT ligand | Growth factor | -4.77 | 1.03E-11 |
| LMNB1 | Lamin B1 | Other | -21.41 | 3.38E-15 |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 | Kinase | -3.95 | 1.61E-11 |
| MAP2K2 | Mitogen-activated protein kinase kinase 2 | Kinase | -3.15 | 4.98E-08 |
| MYC | v-myc myelocytomatosis viral oncogene homolog | Transcription regulator | -5.59 | 5.3E-11 |
| PCNA | Proliferating cell nuclear antigen | Other | -5.98 | 4E-13 |
| PLK1 | Polo-like kinase 1 (Drosophila) | Kinase | -20.76 | 3.1E-14 |
| SHC1 | SHC (Src homolog 2 domain containing) transforming protein 1 | Other | -4.15 | 5.17E-12 |
| TOP2A | Topoisomerase (DNA) II alpha 170 kDa | Enzyme | -156.1 | 1.74E-20 |