Figure 5.

Model for the developmental regulation of CG neuron K_Ca by multiple cell–cell interactions. The data presented in this and previous studies are consistent with a model in which the development of K_Ca is regulated by the combined actions of at least three differentiation factors: β-NEU1 (stimulatory, derived from preganglionic nerve terminals); TGFβ1/4 (stimulatory, derived from ocular target tissues); and TGFβ3 (inhibitory, also derived from ocular target tissues). The balance of the in vivo activities of these factors is such that disruption of interactions with either the target tissues or the afferent input prevents the normal development of functional plasma membrane K_Ca.