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. Author manuscript; available in PMC: 2011 Jan 18.
Published in final edited form as: J Immunol. 2008 Jul 15;181(2):1224–1231. doi: 10.4049/jimmunol.181.2.1224

Figure 1. CD8 KO rejector mice have high magnitude in vivo cytotoxic effector function which is not mediated by CD4+ T or NK cellular effectors.

Figure 1

FVB/N (H-2q) hepatocytes were transplanted into untreated CD8 KO (H-2b) mice. After graft rejection occurred (MST = 14 days), CD8 KO hosts were left untreated (no Rx), or were depleted of CD4+ T cells (CD8 KO αCD4), NK cells (CD8 KO αNK1.1), or both CD4+ T cells and NK cells (CD8 KO αCD4 αNK1.1) 48 hours prior to the in vivo cytotoxicity assay. The bars represent average cytotoxicity ± standard deviation for each group. Individual cytotoxicity values are represented by the circles. Allocytotoxicity in all groups was statistically similar (p=ns).