Table 1. Distribution of yeast and human liver reads across genomic regions.

The numbers indicate percentages of uniquely aligned yeast and human DRS reads (Table S2) as provided by the SeqSolve software (Integromics, S.L., Spain). The categories shown are not exclusive, and each proportion was computed independently. Hence proportions are not expected to add up to 100%. The relatively high percentage of reads in the category of antisense yeast reads within 1000 nts of 3′ ORF ends is due to ~2000 yeast ORFs whose 3′ ends are close to each other. CDS: Coding sequence, UTR: Untranslated region, ORF: Open reading frame, Transcripts: Within annotated gene boundaries (see also Figure S1 and Table S2).

Human	5′ UTR	3′ UTR	CDS	Introns	Transcripts	±200nts of 5′ ends	±200nts of 3′ ends	±10nts of 3′ ends
Sense	6.46	79.38	1.02	8.8	83.94	0.59	71.32	55.7
Antisense	0.18	2.1	0.23	5.86	7.98	0.1	2.96	1.12

Yeast	CDS	Introns	Transcripts	±1000 nts of 3′ ends of ORFs
Sense	4.68	0.19	4.86	91.36
Antisense	9.16	0.04	9.19	53.04