Table 1.
Summary of genital tract symptoms and eye lesions.
| Days of tamoxyfen treatment | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Symptom | 0 | 10 | 20 | 30 | 40 | 50 | 60 | 70 | 80 | 90 | 100 | 110 | 120 |
| A | Oedema | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 3* | 3* |
| Discharge | 0 | 3 | 2 | 1 | 2 | 1 | 5 | 5 | 3 | 5 | 5 | 3* | 3* | |
| Retinitis | 1 | - | - | - | - | - | 1 | - | - | - | - | - | 3 | |
| B | Oedema | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Discharge | 0 | 3 | 1 | 1 | 1 | 1 | 5 | 5 | 2 | 5 | 5 | 5 | 5 | |
| Retinitis | 1 | - | - | - | - | - | 2 | - | - | - | - | - | 2 | |
| C | Oedema | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 3* | 3* | 1# | 1# |
| Discharge | 0 | 2 | 1 | 5 | 2 | 3 | 5 | 1 | 1 | 3* | 3* | 1# | 1# | |
| Retinitis | 1 | - | - | - | - | - | 1 | - | - | - | - | - | 1 | |
| D | Oedema | 0 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Discharge | 0 | 0 | 2 | 1 | 1 | 3 | 1 | 3 | 2 | 1 | 3 | 2 | 2 | |
| Retinitis | 0 | - | - | - | - | - | 0 | - | - | - | - | - | 2 | |
* group size = 3, # group size = 1, - eyes not examined
Number of dogs having vulva oedema, purulent vaginal discharge and retinitis following oral exposure to tamoxifen at daily doses of either 0.5 mg/kg body weight (groups A and B) or 0.8 mg/kg body weight (groups C and D). Dogs in groups B and D were spayed before the study. Each group consisted initially of 5 dogs, but animals developing pyometra or had eye lesions before tamoxifen exposure were removed from the study thus reducing the group size.