Table 1.

Cases of elevated plasma creatinine levels in children who received intravenous acyclovir

Patient	Magnitude of increase in plasma creatinine (from baseline)	Relevant clinical details	References
1 child	5 fold increase within 2 days	Creatinine returned to normal in 4 days Elevated urea No other pathology reported	[4]
10 children	transient elevation	No further impairment reported	[2]
3 children	4 fold increase within 4 days	Mild reduction in urine output Creatinine returned to normal 1 week following acyclovir discontinuation	[3]
1 child	2 fold increase within 6 days	Creatinine continued to increase following acyclovir discontinuation. Creatinine returned to normal within 1 week Elevated urea Mild proteinuria	[7]
3 children	9 fold increase within 2 to 3 days	High urea Urinary α1-microglobulin and albumin Creatinine returned to normal in 3 - 9 days	[8]
1 child	3 fold increase within 4 days	No other information provided	[5]