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. 2011 Jan 18;6(1):e14524. doi: 10.1371/journal.pone.0014524

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Brenet et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Density plot of GC fraction (fG+fC) vs CpGoe, the observed/expected CG fraction, fCG/(fC*fG) for a 200 bp window surrounding each CpG dinucleotide in the genome. (B) The GC fraction vs. CpGoe is plotted for each annotated CGI in the genome. CGIs are partially defined by GC>0.5 and CpGoe>0.6. (C) The sequence characteristics of DMEs are plotted. DMEs are enriched for regions with moderate CpGoe. (D) The distribution of DME lengths is shown along with dashed red lines representing the 5^th (260 bp) and 95^th (2140 bp) percentiles. The median length is 590 bp.