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. 2011 Jan 18;6(1):e14524. doi: 10.1371/journal.pone.0014524

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Brenet et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Profiles of the composite methylation density surrounding the TSS of transcripts upregulated by decitabine are shown before (red) and after (green) decitabine treatment of M091 cells. For comparison, the composite methylation profile of all genes is shown as in Fig. 5A (grey). Also show is the change in methylation seen for transcripts that are upregulated (blue dashed line) or unchanged (orange dashed line) following decitabine treatment. (B) Profiles of the composite methylation density surrounding the TSS of transcripts downregulated by decitabine are shown before (red) and after (green) decitabine treatment. For comparison, the composite methylation profile of all genes is shown as in Fig. 5A (grey). Also show is the change in methylation seen for transcripts that are downregulated (blue dashed line) or unchanged (orange dashed line) following decitabine treatment.