Table 1.
Spearman correlation of PPID, ePPID and betweenness with protein evolutionary rate.
| Protein interaction datasets | n | PPID vs. dN | ePPID vs. dN | betweenness vs. dN |
|---|---|---|---|---|
| rho(p) | rho(p) | rho(p) | ||
| Y2H-union | 1,104 | -0.0487(1.06e-01) | -0.142(2.25e-06) | -0.0365(2.26e-01) |
| Combined-AP/MS | 922 | -0.158(1.46e-06) | -0.251(1.03e-14) | -0.241(1.21e-13) |
| LC-multiple | 894 | -0.172(2.46e-07) | -0.267(4.72e-16) | -0.186(2.05e-08) |
| Updated-HC | 2,245 | -0.183(2.62e-18) | -0.242(2.58e-31) | -0.128(1.30e-09) |
| DIP-CORE | 1,342 | -0.152(2.33e-08) | -0.254(3.69e-21) | -0.111(4.53e-05) |
| DIP-FULL | 2,572 | -0.233(4.56e-33) | -0.271(1.40e-44) | -0.188(5.90e-22) |
dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which both PPID and protein evolutionary rate are available. rho is Spearman rank correlation coefficient, and p is the corresponding statistical significance. Bold indicates that p is significant at the statistical significance level of 0.05.