Table 2.
The variance of protein evolutionary rate explained by PPID and ePPID when controlling for protein abundance.
| Protein interaction datasets | n | Percent variance explained in dN | |||
|---|---|---|---|---|---|
| PPID(p) | PPID control for Log(abundance)(p) | ePPID(p) | ePPID control for Log(abundance)(p) | ||
| Y2H-union | 793 | 0.110(3.52e-01) | 0.145(2.84e-01) | 0.659(2.22e-02) | 0.547(3.73e-02) |
| Combined-AP/MS | 763 | 2.50(1.13e-05) | 0.906(8.52e-03) | 4.25(9.08e-09) | 0.999(5.73e-03) |
| LC-multiple | 680 | 1.29(3.01e-03) | 1.17(4.72e-03) | 4.11(9.62e-08) | 1.70(6.59e-04) |
| Updated-HC | 1,587 | 0.722(7.04e-04) | 0.547(3.19e-03) | 3.53(4.39e-14) | 1.32(4.60e-06) |
| DIP-CORE | 968 | 0.308(8.42e-02) | 0.109(3.05e-01) | 1.27(4.44e-04) | 0.109(3.05e-01) |
| DIP-FULL | 1,792 | 1.99(2.03e-09) | 0.996(2.32e-05) | 3.99(1.39e-17) | 1.36(7.21e-07) |
dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which PPID, protein evolutionary rate and abundance data are all available. p in column 3 and 5 is the statistical significance of the linear regression of protein evolutionary rate against PPID and ePPID, respectively. p in column 4 and 6 is the statistical significance of the linear regression of protein evolutionary rate against PPID and ePPID when controlling for protein abundance, respectively. Bold indicates that p is significant at the statistical significance level of 0.05.