Table 3.
Spearman correlation and partial Spearman correlation of PPID and ePPID with protein evolutionary rate.
| Protein interaction datasets | n | PPID vs. dN | PPID vs. dN control for abundance | ePPID vs. dN | ePPID vs. dN control for abundance |
|---|---|---|---|---|---|
| rho(p) | rho(p) | rho(p) | rho(p) | ||
| Y2H-union | 793 | -0.0249(4.85e-01) | -0.0260(4.64e-01) | -0.116(1.06e-03) | -0.0930(8.66e-03) |
| Combined-AP/MS | 763 | -0.135(1.85e-04) | -0.0666(6.59e-02) | -0.229(1.51e-10) | -0.103(4.35e-03) |
| LC-multiple | 680 | -0.149(9.75e-05) | -0.134(4.16e-04) | -0.260(6.16e-12) | -0.179(2.14e-06) |
| Updated-HC | 1,587 | -0.140(2.27e-08) | -0.0992(7.24e-05) | -0.208(5.21e-17) | -0.121(1.14e-06) |
| DIP-CORE | 968 | -0.108(7.72e-04) | -0.0679(3.45e-02) | -0.214(1.72e-11) | -0.110(5.65e-04) |
| DIP-FULL | 1,792 | -0.223(1.24e-21) | -0.162(3.31e-12) | -0.252(2.77e-27) | -0.156(2.69e-11) |
dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which PPID, protein evolutionary rate and abundance data are all available. rho is Spearman rank correlation coefficient, and p is the corresponding statistical significance. Bold indicates that p is significant at the statistical significance level of 0.05.