Table 3.
Univariate and multivariate analysis of different prognostic factors in 123 patients with hepatocellular carcinoma (Cox Proportional Hazards Regression)
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Variable | All cases | HR (95% CI) | P value | HR (95% CI) | P value |
| Age (years) | 0.883 | ||||
| ≤47.9a | 59 | 1.0 | |||
| >47.9 | 64 | 1.044 (0.588-1.853) | |||
| Sex | 0.746 | ||||
| Male | 107 | 1.153 (0.489-2.717) | |||
| Female | 16 | 1.0 | |||
| Hepatitis history | 0.806 | ||||
| Yes | 105 | 0.904 (0.405-2.021) | |||
| No | 18 | 1.0 | |||
| AFP (ng/ml) | 0.000 | 0.014 | |||
| ≤20 | 68 | 1.0 | 1.0 | ||
| >20 | 55 | 5.445 (2.852-10.395) | 2.573 (1.209-5.476) | ||
| Liver cirrhosis | 0.807 | ||||
| Yes | 87 | 1.0 | |||
| No | 36 | 1.082 (0.578-2.026) | |||
| Tumor size (cm) | 0.000 | 0.167 | |||
| ≤5 | 76 | 1.0 | 1.0 | ||
| >5 | 47 | 2.946 (1.640-5.290) | 1.595 (0.823-3.090) | ||
| Tumor multiplicity | 0.000 | 0.077 | |||
| Single | 85 | 1.0 | 1.0 | ||
| Multiple | 38 | 3.768 (2.108-6.735) | 1.790 (0.939-3.414) | ||
| Differentiation | 0. 099 | ||||
| Well-moderate | 85 | 1.0 | |||
| Poor-undifferentiated | 38 | 1.642 (0.911-2.958) | |||
| Stage | 0.000 | 0.363 | |||
| I-II | 61 | 1.0 | 1.0 | ||
| III -IV | 62 | 5.828 (2.722-12.480) | 1.571 (0.593-4.162) | ||
| Vascular invasion | 0.000 | 0.015 | |||
| Yes | 55 | 5.372 (2.724-10.595) | 2.724 (1.214-6.113) | ||
| No | 68 | 1.0 | 1.0 | ||
| Relapse | 0.000 | 0.321 | |||
| Yes | 42 | 2.885 (1.608-5.174) | 1.390 (0.725-2.666) | ||
| No | 81 | 1.0 | 1.0 | ||
| p300 | 0.001 | 0.021 | |||
| Low expression | 63 | 1.0 | 1.0 | ||
| High expression | 60 | 2.792 (1.533-5.087) | 2.077 (1.149-4.112) | ||
| Ki67 | 0.089 | ||||
| Low expression | 68 | 1.0 | |||
| High expression | 50 | 1.661 (0.925-2.982) | |||
aMean age; AFP, alpha-fetoprotein; HR, hazards ratio; CI, confidence interval.