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. 2011 Jan 18;6(1):e15894. doi: 10.1371/journal.pone.0015894

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Mosch et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic representation of ADNP protein structure (Uniprot ID Q9H2P0). Positions of the nine zinc-fingers (grey), the homeodomain (orange), the nuclear localization signal (NLS) and the ARKS and PGVLL motifs are indicated. (B) NIH3T3 cells were transfected with CFP-ADNP, CFP-ADNP(D741-846) (homeodomain deletion), CFP-ADNP(701-846) (NLS and the homeodomain) and RFP-HP1β. Only cells of low to medium expression levels showed distribution of wt CFP-ADNP similar to the endogenous protein. Therefore, the images show CFP and RFP fluorescence signals of selected unfixed, living cells of low expression levels of the different CFP-fusion proteins using a confocal microscope. Bars, 5 µm.