Figure 1.

Effects of acute inflammation on sickness and depression-like behavior in mice; involvement of kinin B₁ receptor. Effect of systemic administration of E. coli LPS (450 μg/kg, i.p., 24 h and 48 h beforehand) on immobility time in mice submitted to a previous 5-min swimming session in the tail suspension test (a). Influence of imipramine (10 mg/kg i.p.), given 30 min before, on the increased immobility time in pre-stressed animals treated with E. coli LPS. (b) Effect of the selective kinin B₂ receptor antagonist FR173657 (5 mg/kg, i.p., 30 min). (c) Effect of the selective kinin B₁ receptor antagonists R-715 (0.5 mg/kg, i.p., 30 min) or SSR240612 (5 mg/kg, i.p., 30 min or 10 mg/kg, p.o., 1 h). (d) Effect of systemic administration of E. coli LPS (450 μg/kg, i.p.) after three days of forced swimming on sucrose intake; influence of imipramine (10 mg/kg, i.p., 30 min) or SSR240612 (10 mg/kg p.o., 1 h) treatment. (e) Effect of E. coli LPS (450 μg/kg, i.p., 6 h and 24 h) on body temperature, in mice submitted to a previous 5-min swimming session; influence of treatment with R-715 (0.5 mg/kg, i.p., 30 min). Effect of systemic administration of E. coli LPS (450 μg/kg, i.p., 6 h and 24 h) on locomotor activity in mice submitted to a previous 5-min swimming session (f). Each column or point represents the mean of 6-8 animals and vertical lines show the SEM. **P < 0.01 compared to vehicle and ^#P < 0.05, ^##P < 0.01 compared LPS-treated mice.