Table I.
Summary of normalized TF activity for large-scale activity array and statistical significance.
| TF | TF activity |
P-value | |
|---|---|---|---|
| Average | Standard deviation | ||
| Control | 1.000 | 0.074 | 1 |
| p53 | 7.487 | 1.214 | 1.79E−92 |
| AP1 | 2.620 | 0.280 | 1.69E−65 |
| CRE | 1.442 | 0.150 | 5.54E−24 |
| HIF-1 | 1.307 | 0.094 | 2.61E−19 |
| NFκB | 1.291 | 0.106 | 8.13E−18 |
| ER | 1.284 | 0.135 | 4.57E−13 |
| SP1 | 1.259 | 0.138 | 1.27E−11 |
| GATA4 | 1.144 | 0.078 | 2.03E−04 |
| SRF | 1.107 | 0.116 | 1.04E−01 |
| E2F1 | 1.101 | 0.151 | 1.85E−02 |
| AP2 | 1.085 | 0.117 | 1.00E+00 |
| AP4 | 1.071 | 0.110 | 1.00E+00 |
| GATA | 1.047 | 0.089 | 1.00E+00 |
| IRF-1 | 1.045 | 0.049 | 1.00E+00 |
| SRE | 1.044 | 0.150 | 1.00E+00 |
| VDR | 1.034 | 0.082 | 1.00E+00 |
| GAS | 1.030 | 0.083 | 1.00E+00 |
| NFAT | 1.018 | 0.112 | 1.00E+00 |
| GATA1/2 | 1.017 | 0.082 | 1.00E+00 |
| Smad 3/4 | 1.016 | 0.110 | 1.00E+00 |
| YY1 | 1.013 | 0.090 | 1.00E+00 |
| AR | 0.991 | 0.072 | 1.00E+00 |
| AP3 | 0.988 | 0.089 | 1.00E+00 |
| GR | 0.986 | 0.082 | 1.00E+00 |
| PR | 0.977 | 0.132 | 1.00E+00 |
| HSE | 0.977 | 0.068 | 1.00E+00 |
| Smad | 0.976 | 0.111 | 1.00E+00 |
| MEF-3 | 0.973 | 0.092 | 1.00E+00 |
| MEF-2 | 0.970 | 0.077 | 1.00E+00 |
| MEF-1 | 0.957 | 0.063 | 1.00E+00 |
| STAT4 | 0.950 | 0.076 | 1.00E+00 |
| GATA3 | 0.950 | 0.083 | 1.00E+00 |
TFs in bold are considered to have statistically significant higher activity than the TA vector control using Bayesian-based comparisons and an FDR corrected α′ = 0.00015.