Table 4.
Results of neutralization test with poliovirus type 1 strain CHAT and Poliovirus Type 1 Strain Sabin (LSc-2ab) in three different laboratories.
| Laboratory Nr. 1 | Laboratory Nr. 2 | Laboratory Nr. 3 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Case No. |
CHAT ATTC VR-1562 |
Sabin 1 WHO reference strain |
Ratio* | CHAT ATTC VR-1562 |
Sabin 1 WHO reference strain |
Ratio | CHAT ATTC VR-1562 |
Sabin 1 WHO reference strain |
Ratio |
| GMT** (IU/ml) | GMT (IU/ml) | GMT IU/ml | GMT IU/ml | GMT IU/ml | GMT IU/ml | ||||
| 7b | < 8 (< 1,1) | 91 (4,9) | > 4,5 | 12 (0,6) | 192 (4,1) | 7,1 | < 10 (< 1,3) | 80 (5,3) | > 4,1 |
| 9 | 8 (1,1) | 64 (3,4) | 3,1 | 32 (1,5) | 128 (2,7) | 1,8 | < 10 (< 1,3) | 40 (2,7) | > 2,0 |
| 12b | 23 (3,2) | 362 (19,5) | 6,1 | 64 (3,1) | 256 (5,5) | 1,8 | 10 (2,6) | 160 (10,6) | 4,1 |
| 13b | 32 (4,4) | > 786 (> 42,3) | > 9,4 | 48 (2,3) | > 512 (> 11) | > 4,7 | 20 (5,2) | 640 (42,4) | 8,2 |
| 28b | 32 (4,4) | 64 (3,4) | 0,8 | 96 (4,6) | 128 (2,7) | 0,6 | 20 (5,2) | 40 (2,7) | 0,5 |
| 16b | 64 (8,9) | 512 (27,5) | 3,1 | 128 (6,2) | 512 (11,0) | 1,8 | 20 (5,2) | 320 (21,2) | 4,1 |
| 21 | 128 17,8 | 2048 110,1 | 6,2 | 384 (18,6) | > 512 (> 11) | > 0,6 | 40 (10,4) | 1280 (84,8) | 8,2 |
| 8b | 256 (35,6) | 362 (19,5) | 0,5 | 512 (24,8) | 512 (11,0) | 0,4 | 80 (20,7) | 320 (21,2) | 1,0 |
| 34b | 256 (35,6) | > 786 (> 42,3) | > 1,9 | > 512 (> 25) | > 512 (> 11) | - | 80 (20,7) | 320 (21,2) | 1,0 |
| Internal control | 41 (5,7) | 106 (5,7) | 1,0 | 62 (3) | 140 (3) | 1,0 | 22 (5,7) | 86 (5,7) | 1,0 |
Laboratory Nr. 1 - Labor Enders, Stuttgart, Laboratory Nr. 2 - Robert Koch-Institute (RKI), Berlin, Laboratory Nr. 3 - Institute for Medical Virology, Johann Wolfgang Goethe-University of Frankfurt
*Ratio of IU/ml Sabin to IU/ml CHAT
**GMT Reciprocal geometric mean titers