Table 2.

Random-effect linear regression analyses of trend of CD4 count (slope, cells/μL per year)

	Univariate			Multivariate**
	Difference*	(95% CI)	p value	Difference*	(95% CI)	p value
Sex
Male*	0.0			0.0
Female	9.5	(0.1, 18.9)	0.047	7.8	(-1.5, 17.2)	0.099
Current age
per 10 years older	-6.5	(-10.3, -2.7)	0.001	-4.8	(-8.6, -1.0)	0.013
Disease stage
CDC Category A*	0.0			0.0
TB with or without other ADI	24.4	(13.7, 35.1)	< 0.001	26.3	(15.6, 37.0)	< 0.001
Non-TB ADI(s)	3.7	(-5.6, 13.0)	0.433	12.0	(2.5, 21.4)	0.013
Haemglobin level
per 1 g/dL higher	0.0	(-0.0, 0.1)	0.661	0.0	(-0.0, 0.1)	0.689
Concurrent CD4 count
Per 100 cells/μL higher	1.3	(-0.3, 3.0)	0.116	1.9	(0.2, 3.7)	0.033
Concurrent viral load
per log10 copies/mL higher	-40.9	(-48.7, -33.2)	< 0.001	-40.5	(-48.4, -32.6)	< 0.001
Hepatitis B or C coinfection
No*	0			0
Yes	-19.1	(-31.1, -7.0)	0.002	-17.7	(-29.7, -5.7)	0.004
Time since cART initiation
> 6 to ≤ 12 months*	0.0			0.0
> 12 to ≤ 18 months	-21.3	(-37.7, -5.0)	0.011	-21.5	(-37.8, -5.2)	0.010
> 18 to ≤ 24 months	-23.1	(-39.3, -7.0)	0.005	-25.8	(-42.0, -9.7)	0.002
> 24 or more months	-58.0	(-70.3, -45.7)	< 0.001	-59.1	(-71.7, -46.5)	< 0.001
Initial cART containing NNRTI
No*	0.0			0.0
Yes	6.4	(-1.4, 14.1)	0.106	-1.3	(-9.2, 6.6)	0.749
Initial cART containing boosted PI
No*	0.0			0.0
Yes	-0.8	(-10.5, 9.0)	0.880	-3.4	(-13.2, 6.3)	0.493
Initial cART containing abacavir
No*	0.0
Yes	-12.9	(-25.8, 0.0)	0.050	-5.6	(-18.5, 7.3)	0.397

* Difference were compared with the first category of each categorical variable.

** Constant term for multivariate model: 205.5 (174.4, 236.6) cells per μL per year.