Table 4.
Final model | Initial treatment, before any class change or stop for more than 30 days | Initial NNRTI-based regimen, before change or stop for more than 30 days | Including patients with 4 or more CD4 slopes endpoints | |||||
---|---|---|---|---|---|---|---|---|
Difference* | (95% CI) | Difference* | (95% CI) | Difference* | (95% CI) | Difference* | (95% CI) | |
Observations = 10899 | Observations = 6697 | Observations = 4058 | Observations = 9826 | |||||
Patients = 1676 | Patients = 1353 | Patients = 863 | Patients = 1079 | |||||
Current age, per 10 yrs older | ||||||||
per unit | -4.8 | (-8.6, -1.0) | -4.0 | (-9.0, 1.0) | -2.4 | (-9.2, 4.4) | -4.3 | (-8.4, -0.2) |
Concurrent viral load, per log10 copies per mL higher | ||||||||
per unit | -40.5 | (-48.4, -32.6) | -43.4 | (-58.5, -28.4) | -45.1 | (-68.0, -22.2) | -39.5 | (-48.1, -30.9) |
Concurrent CD4 per 100 per μL higher | ||||||||
per unit | 1.9 | (0.2, 3.7) | 3.4 | (1.0, 5.7) | 4.1 | (0.9, 7.3) | 1.9 | (0.0, 3.8) |
Disease stage | ||||||||
CDC Category A* | 0.0 | 0.0 | 0.0 | 0.0 | ||||
TB and/or other ADI | 26.3 | (15.6, 37.0) | 29.9 | (16.1, 43.7) | 29.9 | (13.9, 45.9) | 26.4 | (14.6, 38.1) |
Non-TB ADI(s) | 12.0 | (2.5, 21.4) | 16.4 | (3.4, 29.4) | 16.3 | (-1.2, 33.9) | 11.2 | (0.9, 21.6) |
Hepatitis B or C coinfection | ||||||||
No* | 0.0 | 0.0 | 0.0 | 0.0 | ||||
Yes | -17.7 | (-29.7, -5.7) | -17.5 | (-33.1, -2.0) | -19.8 | (-39.6, 0.0) | -18.7 | (-31.9, -5.5) |
Time since ART initiation | ||||||||
> 6 to ≤ 12 months* | 0.0 | 0.0 | 0.0 | 0.0 | ||||
> 12 to ≤ 18 months | -21.5 | (-37.8, -5.2) | -29.4 | (-48.2, -10.6) | -16.3 | (-40.9, 8.3) | -19.6 | (-37.8, -1.4) |
> 18 to ≤ 24 months | -25.8 | (-42.0, -9.7) | -32.8 | (-51.9, -13.7) | -13.9 | (-38.8, 10.9) | -25.8 | (-43.6, -7.9) |
> 24 or more months | -59.1 | (-71.7, -46.5) | -65.6 | (-80.7, -50.5) | -55.4 | (-75.3, -35.5) | -59.1 | (-73.1, -45.0) |
Constant | 205.5 | (174.4, 236.6) | 207.2 | (157.7, 256.6) | 192.8 | (121.4, 264.2) | 200.6 | (166.6, 234.6) |
* Difference were compared with the first category of each categorical variable