Table 3.
Analysis of the reported allele and genotype frequencies of rs1156044 in Han Chinese and Japanese
| Population and sample size | Genotype | P-valuea | Allele | P-valuea | Data source | |||
|---|---|---|---|---|---|---|---|---|
| A/A (%) | A/G (%) | G/G (%) | A (%) | G (%) | ||||
| 1. SZ-HC (n = 529) | 292 (55.2) | 195 (36.9) | 42 (7.9) | 0.023 (1 vs. 3) | 779 (73.6) | 279 (26.4) | 0.005 (1 vs. 3) | This study |
| 0.018 (1 vs. 4) | 0.044 (1 vs. 4) | |||||||
| 0.346 (1 vs. 5) | 0.459 (1 vs. 5) | |||||||
| 2. CT-HC (n = 505) | 299 (59.2) | 180 (35.6) | 26 (5.2) | 0.0003 (2 vs. 3) | 778 (77.0) | 232 (23.0) | 0.0004 (2 vs. 3) | This study |
| 0.001 (2 vs. 4) | 0.001 (2 vs. 4) | |||||||
| 0.076 (2 vs. 5) | 0.030 (2 vs. 5) | |||||||
| 3. SZ-JP (n = 212) | 94 (44.3) | 95 (44.8) | 23 (10.8) | 0.264 (3 vs. 6) | 283 (66.7) | 141 (33.3) | 1.000 (3 vs. 6) | Washizuka et al. 2006 |
| 4. CT-JP (n = 222) | 99 (44.6) | 106 (47.7) | 17 (7.7) | 0.041 (4 vs. 6) | 304 (68.5) | 140 (31.5) | 0.663 (4 vs. 6) | Washizuka et al. 2006 |
| 5. CT-CHB+CHD (n = 243) | 123 (50.6) | 103 (42.4) | 17 (7.0) | 0.055 (5 vs. 6) | 349 (71.8) | 137 (28.2) | 0.187 (5 vs. 6) | HapMap dataset |
| 6. CT-JPT (n = 113) | 55 (48.7) | 41 (36.3) | 17 (15.0) | -- | -- | -- | -- | HapMap dataset |
Note: SZ-HC and CT-HC refer to Han Chinese with and without schizophrenia, respectively. CT-CHB = Beijing Han Chinese from HapMap; CHD = Chinese in Metropolitan Denver from HapMap; CT-JPT = Japanese in Tokyo from HapMap; SZ-JP and CT-JP refer to Japanese patients with and without schizophrenia from Washizuka et al. [5]. We did not include the reported Han Chinese data in Zhang et al's study [7] for comparison, as there is inconsistency about the sample size in their text. a two-tailed Fisher's Exact Probability Test P value