Table 2.
Summary of major QTLs detected in the F2 mice.
| Chr | Best location, cM (CI) |
Closest marker to peak LOD |
Peak LOD | GW Sig. | % | Phenotype value | |||
|---|---|---|---|---|---|---|---|---|---|
| B6/B6 (n) | B6/TH (n) | TH/TH (n) | |||||||
| Triglyceride (mg/dl) | |||||||||
| 8 wk | 1 | 95.7 (25.7, 96.9) |
D1Mit113 | 3.67 | S | 3.63 | 157 ± 7 (89)a | 164 ± 4 (201)a | 188 ± 6 (78)b |
| 12 wk | 11 | 65 (20, 79) |
D11Mit132 | 3.76 | S | 1.72 | 153 ± 5 (90)a | 169 ± 4 (182)b | 173 ± 6 (109)b |
| 20 wk | 4 | 31.3 (21.3, 41.3) |
D4Mit178 | 4.47 | VS | 4.82 | 161 ± 6 (92)a | 178 ± 5 (201)a | 210 ± 9 (83)b |
| 24 wk | 8 | 55.75 (50, 55.7) |
D8Mit242 | 3.94 | S | 4.29 | 159 ± 7 (97)a | 185 ± 5 (186)b | 199 ± 8 (91)b |
| Cholesterol (mmol/l) | |||||||||
| 8 wk | 1 | 86.7 (84.7, 87.7) |
D1Mit113 | 11.83 | VS | 4.96 | 2.5 ± 0.1 (88)a | 2.9 ± 0.1 (200)b | 3.2 ± 0.1 (77)c |
| 12 wk | 1 | 89.7 (86.7, 96.7) |
D1Mit113 | 6.55 | VS | 6.76 | 2.6 ± 0.1 (88)a | 3.2 ± 0.1 (211)b | 3.5 ± 0.1 (79)c |
| 3 | 10.6 (5.6, 11.6) |
D3Mit304 | 4.07 | S | 4.31 | 3.5 ± 0.1 (102)a | 3.0 ± 0.1 (177)b | 2.9 ± 0.1 (99)b | |
| 16 wk | 1 | 93.7 (86.7, 96.9) |
D1Mit113 | 7.99 | VS | 8.62 | 2.6 ± 0.1 (92)a | 3.0 ± 0.1 (212)b | 3.5 ± 0.1 (80)c |
| 20 wk | 1 | 92.7 (86.7, 96.9) |
D1Mit113 | 9.83 | VS | 11.05 | 2.8 ± 0.1 (89)a | 3.2 ± 0.1 (209)b | 3.9 ± 0.1 (79)c |
| Glucose (mg/dl) | |||||||||
| 24 wk | 4 | 67.3 (66.3, 70.3) |
D4Mit312 | 6.13 | VS | 2.89 | 147 ± 4 (102)a | 167 ± 4 (205)b | 172 ± 8 (66)b |
| Body weight (g) | |||||||||
| 20 wk | 11 | 41 (32, 43) |
D11Mit41 | 4.51 | VS | 2.17 | 36 ± 0.5 (72)a | 38 ± 0.4 (199)b | 38 ± 0.5 (103)b |
| 24 wk | 11 | 41 (32, 43) |
D11Mit41 | 4.43 | VS | 1.74 | 38 ± 0.6 (72)a | 40 ± 0.4 (197)b | 40 ± 0.6 (103)b |
| 1 | 35.7 (33.7, 44.7) |
D1Mit215 | 3.52 | S | 4.15 | 37 ± 0.6 (92)a | 40 ± 0.4 (180)b | 41 ± 0.6 (101)b | |
| Fat pad weight (g) | |||||||||
| IG | 1 | 41.7 (33.7, 44.7) |
D1Mit215 | 5.38 | VS | 5.88 | 0.79 ± 0.05 (92)a | 1.02 ± 0.04 (179)b | 1.12 ± 0.05 (101)b |
| ED | 1 | 39 (33.7, 44.7) |
D1Mit215 | 6.20 | VS | 7.02 | 1.15 ± 0.06 (92)a | 1.43 ± 0.05 (179)b | 1.61 ± 0.06 (101)c |
| MS | 1 | 41.7 (33.7, 44.7) |
D1Mit215 | 4.14 | S | 4.78 | 0.32 ± 0.02 (92)a | 0.42 ± 0.02 (179)b | 0.43 ± 0.02 (101)b |
| RP | 1 | 39 (33.7, 44.7) |
D1Mit215 | 4.62 | VS | 5.40 | 0.33 ± 0.02 (91)a | 0.44 ± 0.02 (179)b | 0.47 ± 0.02 (101)b |
| SC | 1 | 39 (33.7, 44.7) |
D1Mit215 | 6.39 | VS | 7.24 | 0.37 ± 0.03 (92)a | 0.54 ± 0.03 (179)b | 0.56 ± 0.03 (101)b |
| Sum | 1 | 40.7 (33.7, 44.7) |
D1Mit215 | 6.26 | VS | 7.01 | 2.9 ± 0.16 (92)a | 3.8 ± 0.13 (179)b | 4.2 ± 0.18 (101)b |
| Carcass weight (g) | |||||||||
| 11 | 40 (32, 43) |
D11Mit41 | 4.48 | VS | 1.88 | 32 ± 0.4 (72)a | 34 ± 0.3 (197)b | 34 ± 0.4 (102)b | |
| 14 | 72.5 (65.5, 76.1) |
D14Mit107 | 3.67 | S | 4.53 | 34 ± 0.5 (81)a | 34 ± 0.3 (193)a | 32 ± 0.4 (96)b | |
Phenotypic data are presented as mean ± sem. Means labeled with different letters are significantly different from one another (P < 0.05). Chr, chromosome; CI, 2 LOD support interval; %, total variance explained by R-square; IG, inguinal; ED, epididymal; MS, mesenteric; RP, retroperitoneal including perirenal; SC, subscapular; Sum, sum of the 5 fat pads above; GW Sig., genome-wide significance; S, significant; VS, very significant.