Table 5.
Correlations of the gene expression levels with physiological traits.
| Tissue | Positively correlated |
Negatively correlated |
Trait |
|---|---|---|---|
| Near D1Mit113 | |||
| Adipose tissue | Prrx1, Creg1, Nuf2, Sh2d1b1, Fcgr4, Fcgr3, Fcer1g, Adamts4, Cd84, Pea15a, Atp1a4, Slamf9, Tagln2, Vsig8, Slamf8, Wdr26, Degs1, Kctd3, Atf3 | Gas5, Opn3, Sdccag8, Hnrnpu, Trp53bp2, Iars2, Ptpn14 | BW FPW |
| Muscle | Sft2d2, Dedd, |
Sdhc Mrps14, Prrx1, Nme7, Mpzl1, Cd247, Lrrc52, Fcrla, Adamts4, Pvrl4, Cd244, Slamf7, Igsf9, Tagln2 |
Chol Tg |
| Near D11Mit132 | |||
| Adipose tissue | Ccl6, Rab5c, Atp6v0a1, Psmc3ip, Tubg1, Psme3, Dusp3, Grn, Nmt1, Plekhm1, Cdc27, Mrc2, Tanc2, Wipi1, Kpna2 | Stat5b, Rdm1, Rprml, Helz | BW FPW |
| Muscle | Prkar1a, Sgca, Spop, Krtap3-1 | Fkbp10, Acly, Stat3, Vps25, Cntd1, Psme3, Ifi35, Brca1, Slc25a39, Gpatch8, Gm1564, Eftud2, Hexim2, Lyzl6, Wnt3, Crhr1, Arsg, Slfn10, Slfn3, Kal1, Lhx1, Ggnbp2, Usp32, Ptrh2, Dhx40, Rad51c, Msi2, Car10, Mbtd1, Mycbpap, Rsad1, Hils1, Zfp652, Ube2z, Calcoco2, Skap1, Scrn2, Kpnb1, Pip4k2b, Med1, Crkrs, Gsdma2, Wipf2, Krt12 | Tg |
| Near D4Mit178 | |||
| Adipose tissue | Col15a1, Nipsnap3a, Svep1, Slc31a1, Orm1, Tnc, Megf9, Mpdz | Rgs3, Orm3 | BW FPW |
| Muscle | Mup4, Mup3, Zfp37, Orm2, Pappa, Dbc1, Cdk5rap2, Rasef | Tg | |
| Near D8Mit242 | |||
| Adipose tissue | Tmem208, Lypla3, Cyb5b, Hp, Mlkl, Cenpn, Gcsh, Cotl1, Gins2 | Cirh1a, Ces3, Bbs2, Terf2ip, Fbxo31 | BW FPW |
| Muscle | Cog8, Znrf1, Gse1 | Cdh8, Cklf, Cmtm2a, Ccdc79, Lcat, Prmt7, Sntb2, Adat1, Terf2ip, Mon1b, Jph3, Cdt1, Zfp319, Gins3, Setd6 | Tg |
| Near D3Mit304 | |||
| Muscle | Agtr1b, Tbl1xr1, Arpm1, Samd7, Cldn11, Slc7a14, Pik3ca, Ccdc39, Sox2 | Tg | |
| Adipose tissue | Fabp5, Sirpb1, Aadacl1, Tpd52 | Lrrcc1, Car3, Mynn, Phc3, Zfhx4 | BW FPW |
| Near D4Mit312 | |||
| Muscle | Nadk | Eif4g3, Ubxd3, Pax7, Arhgef19, Tnfrsf8, Rex2, Clcn6, Fbxo6, Gpr153, Morn1, Gabrd, Ssu72, Ttll10, Dhdds, Lin28, Sepn1, Srrm1, Rcan3, Cnr2, Htr1 d, Ephb2, Ptafr, Eya3 | Tg |
| Adipose tissue | Efhd2, Lzic, Pgd, Plod1, Dnajc16, Necap2, Mfap2, Atp13a2, Igsf21, Capzb, Pla2g2e, Hspg2, C1qc, Ephb2, Clic4, Ldlrap1, Paqr7, Stmn1 | Sdf4, Thap3, Per3, Park7, H6pd, Tmem201, Tardbp, Gale, Srrm1, Syf2, Tmem57 | BW FPW |
| Near D11Mit41 | |||
| Adipose tissue | Eif4a1, Atp6v0a1, Psmc3ip, Dusp3, Nmt1, Mpdu1, Cd68, Garnl4, Serpinf1, Slc43a2, Pitpna, Blmh, Pigs, Evi2a, Rhbdl3, Ccl2, Ccl7, Ccl9, Ccl6, Ccl3, Dynll2, Mmd, Lrrc59, Col1a1, Top2a |
Rdm1, Ssh2, Unc45b, Acaca, Ggnbp2, Med13, Vezf1, Tmem100, Spop, Kpnb1, Erbb2, Thra, |
BW FPW |
| Muscle | Sgca, Spop, Krtap3-1 | Fkbp10, Acly, Cntd1, Ifi35, Lyzl6, Aurkb, Trp53, Alox12, Itgae, Phf12, Nek8, Spag5, Nos2, Rhot1, Zfp207, Fndc8, Slfn10, Slfn3, Kal1, Lhx1, Ggnbp2, Usp32, Ptrh2, Dhx40, Rad51c, Msi2, Car10, Mbtd1, Mycbpap, Rsad1, Hils1, Zfp652, Ube2z, Calcoco2, Skap1, Scrn2, Kpnb1, Pip4k2b, Crkrs, Gsdma2, Wipf2, Krt12 | Tg |
| Near D1Mit215 | |||
| Adipose tissue | Slc11a1, Col6a3 | Ikzf2, Usp37, Cyp27a1, Mogat1, Irs1 | BW FPW |
| Liver | Igfbp2 | FPW | |
| Muscle | Sumo1, Spag16, Tnp1, Vil1, Plcd4, Zfp142, Ttll4, Cyp27a1, Des, Epha4, Pax3, Mrpl44, Cops7b, Chrng | Tg | |
| Near D14Mit107 | |||
| Adipose tissue | Dock9 | BW FPW |
|
| Muscle | Dock9, Dzip1, Oxgr1, Ipo5, Farp1, Fgf14, | Tg | |
Genes located in physiological trait QTL intervals, showing correlations of the gene expression levels with physiological traits (P < 0.05) are detected by microarray and regression analyses using the subset of F2 mice (n = 16). Genes in bold are confirmed by qRT-PCR. BW, body weight; FPW, fat pad weight; Chol, cholesterol; Tg, triglyceride.