Fig. 5.

MnP prevents activation of redox-active cellular transcription factors. In an in vitro 4T1 mouse breast cancer cell study, HIF-1α was activated by H₂O₂ and nitric oxide but blocked with equimolar concentrations of MnTE-2-PyP⁵⁺, indicated in I as SOD (Moeller et al. 2004). In II, the AP-1 activation in a mouse skin cancerogenesis model was inhibited with MnTE-2-PyP⁵⁺ given at 5 ng daily for 5 days a week for 4 weeks (Zhao et al. 2005), while in III, in a rat stroke 90-min middle cerebral artery (MCAO) occlusion model, the NF-κB activation at 6 h post-MCAO was inhibited with imidazolyl analog, MnTDE-2-ImP⁵⁺, given for 1 week intracerebroventricularly (ICV) at 900 ng bolus dose + 56 ng/h ICV infusion for a week starting at 90 min after 90-min MCAO (Sheng et al. 2009)