Table 3.

Median mRNA levels (and ranges) of 15 genes and 2 microRNAs in the 1.4-Mb deletion in dermal and plexiform neurofibromas and MPNSTs.

Genes	Alternative symbols	Dermal neurofibromas (n = 23)	Plexiform neurofibromas (n = 13)	MPNSTs (n = 13)	Pa	Pb
LRRC37B2	DKFZp667M2411	1.00 (0.54–1.90)	1.16 (0.49–2.71)	1.22 (0.47–1.89)	NS	NSc
CRLF3	CYTOR4	1.00 (0.42–1.88)	1.25 (0.66–1.97)	0.76 (0.17–2.32)	NS	NS
ATAD5	FLJ12735	1.00 (0.38–2.52)	1.19 (0.65–1.62)	3.02 (0.44–9.55)	NS	1.4 × 10−4
C17orf42	FLJ22729	1.00 (0.62–1.79)	1.24 (0.53–3.63)	1.14 (0.27–2.71)	NS	NS
CENTA2	HSA272195	1.00 (0.62–2.27)	0.95 (0.53–4.59)	0.38 (0.15–1.89)	NS	0.014
RNF135	MGC13061	1.00 (0.41–1.68)	0.92 (0.57–1.37)	0.49 (0.13–1.74)	NS	0.026
NF1	—	1.00 (0.81–1.27)	1.01 (0.49–1.84)	0.93 (0.38–2.25)	NS	NS
OMG	OMGP	1.00 (0.52–1.57)	1.65 (0.51–3.09)	0.92 (0.32–2.16)	0.013	NS
EVI2B	—	1.00 (0.54–1.75)	0.74 (0.59–1.82)	0.30 (0.14–1.47)	NS	6 × 10−4
EVI2A	—	1.00 (0.46–1.94)	1.10 (0.46–3.16)	2.03 (0.44–6.93)	NS	0.047
RAB11FIP4	Rab11-FIP4	1.00 (0.37–4.12)	1.23 (0.47–3.23)	0.99 (0.23–5.07)	NS	NS
MIRN193A	hsa-mir-193a	1.00 (0.64–1.48)	0.65 (0.38–1.35)	0.77 (0.40–2.83)	NS	NS
MIRN365-2	hsa-mir-365-2	1.00 (0.55–1.95)	1.49 (0.77–2.35)	0.84 (0.44–1.89)	NS	NS
C17orf79	HSA272196	1.00 (0.35–1.89)	0.95 (0.18–1.69)	2.58 (0.86–4.53)	NS	0.006
UTP6	HCA66, C17orf40	1.00 (0.38–1.51)	1.09 (0.57–1.71)	0.83 (0.32–2.51)	NS	NS
SUZ12	JJAZ1, KIAA0160	1.00 (0.47–1.81)	1.90 (1.02–3.83)	0.96 (0.31–3.31)	2 × 10−4	NS
LRRC37B	LOC114659	1.00 (0.10–2.07)	0.83 (0.16–1.62)	0.94 (0.54–1.96)	NS	NS
MKI67		1.00 (0.30–2.82)	1.54 (0.88–4.77)	30.7 (13.6–82.9)	0.012	8 × 10−6

Data are median (range) mRNA levels, unless otherwise indicated. Bold data indicate significantly different expression.

^aMann–Whitney U test: plexiform neurofibromas versus dermal neurofibromas.

^bMann–Whitney U test: MPNSTs versus dermal neurofibromas.

^cNS, not significant.