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(A) Complicated restenosis following balloon angioplasty, neointimal hyperplasia, macrophage deposition, and VSMC proliferation (VSMCs/PCNA) in carotid artery of control vehicle-treated LDL receptor-deficient mice. (B) Treatment with aspirin (54 mg/kg; protocol 1) reduced intima remodeling and the degree of VSMC proliferation. (C) NCX-4016 (30 mg/kg; protocol 1) showed a more significant reduction of neointimal hyperplasia and VSMC proliferation.
