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. 2011 Jan 17;208(1):3–11. doi: 10.1084/jem.20100027

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© 2011 Viret et al.

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Figure 3. — Impaired thymic selection of HEL-specific CD4 T cells in Tssp^−/− mice. WT or Tssp^−/− (KO) mice were lethally irradiated before reconstitution with WT BM cells (WT) or a 1:1 mix of WT and NOD-Cα° TSSP-deficient (Cα°-KO) BM cells, as indicated (BM → host). 8–10 wk after reconstitution, chimeras were immunized with HEL protein, and 7 d later, their CD4 T cell proliferative response to 10 µg/ml HEL_12–27 pulsed WT APCs was analyzed. The results of three independent experiments are expressed as the ratio of the proliferation of WT or TSSP-deficient CD4 T cells (X) divided by the mean value of the WT control chimeras in the same experiment. Each symbol corresponds to one individual chimera. Horizontal bars represent the mean. Significant p-values are shown.