TABLE 2.
Odds ratios (ORs) and 95% confidence intervals (CIs) for fat and protein intake and risk of distal colorectal cancer: North Carolina Colon Cancer Study–Phase IIa
| Nutrient Quartiles (Q) | Whites (n = 1,520) |
African Americans (n = 384) |
||||||
|---|---|---|---|---|---|---|---|---|
| Cases/Controls | Median Intake/Day in Controls | OR | 95% CI | Cases/Controls | Median Intake/Day in Controls | OR | 95% CI | |
| Total fat (g) | ||||||||
| Q1 | 146/200 | 45.2 | 1.00 | 55/40 | 42.7 | 1.00 | ||
| Q2 | 156/200 | 67.7 | 0.98 | 0.68–1.39 | 46/40 | 69.8 | 0.55 | 0.26–1.14 |
| Q3 | 206/200 | 91.5 | 1.21 | 0.80–1.82 | 67/40 | 99.6 | 0.55 | 0.23–1.36 |
| Q4 | 212/200 | 132.3 | 1.01 | 0.56–1.81 | 57/39 | 145.2 | 0.32 | 0.10–1.15 |
| P for linear trend | 0.97 | 0.89 | ||||||
| Total fat (% energy) | ||||||||
| Q1 | 144/200 | 27.3 | 1.00 | 70/40 | 28.1 | 1.00 | ||
| Q2 | 207/201 | 33.6 | 1.36 | 0.98–1.90 | 70/40 | 34.5 | 1.07 | 0.56–2.01 |
| Q3 | 169/199 | 38.1 | 0.92 | 0.65–1.30 | 50/40 | 38.4 | 0.55 | 0.29–1.07 |
| Q4 | 200/200 | 43.3 | 1.00 | 0.71–1.42 | 35/39 | 44.3 | 0.59 | 0.29–1.21 |
| P for linear trend | 0.25 | 0.27 | ||||||
| Saturated fat(g) | ||||||||
| Q1 | 144/200 | 12.9 | 1.00 | 46/40 | 11.8 | 1.00 | ||
| Q2 | 156/200 | 20.0 | 0.96 | 0.67–1.37 | 58/40 | 19.4 | 0.81 | 0.39–1.66 |
| Q3 | 202/200 | 27.9 | 1.14 | 0.76–1.70 | 55/40 | 29.6 | 0.54 | 0.22–1.34 |
| Q4 | 218/200 | 42.1 | 1.05 | 0.61–1.81 | 66/39 | 44.0 | 0.60 | 0.18–1.97 |
| P for linear trend | 0.66 | 0.56 | ||||||
| Saturated fat (%energy) | ||||||||
| Q1 | 133/200 | 7.7 | 1.00 | 64/40 | 7.8 | 1.00 | ||
| Q2 | 184/200 | 9.7 | 1.12 | 0.80–1.58 | 71/40 | 9.8 | 1.13 | 0.60–2.15 |
| Q3 | 173/202 | 11.5 | 0.95 | 0.67–1.35 | 43/40 | 11.4 | 0.52 | 0.26–1.04 |
| Q4 | 230/198 | 13.8 | 1.27 | 0.88–1.84 | 47/39 | 13.6 | 0.69 | 0.33–1.42 |
| P for linear trend | 0.27 | 0.004 | ||||||
| Monounsaturated fat(g) | ||||||||
| Q1 | 151/200 | 17.2 | 1.00 | 57/40 | 15.5 | 1.00 | ||
| Q2 | 161/200 | 26.4 | 0.98 | 0.69–1.39 | 48/40 | 27.1 | 0.56 | 0.27–1.13 |
| Q3 | 192/200 | 35.1 | 1.03 | 0.69–1.53 | 60/40 | 39.0 | 0.57 | 0.24–1.37 |
| Q4 | 216/200 | 51.8 | 0.89 | 0.51–1.55 | 60/39 | 56.7 | 0.41 | 0.12–1.40 |
| P for linear trend | 0.62 | 0.68 | ||||||
| Polyunsaturated fat (g) | ||||||||
| Q1 | 150/200 | 10.3 | 1.00 | 45/40 | 10.3 | 1.00 | ||
| Q2 | 180/200 | 15.8 | 1.12 | 0.79–1.58 | 57/40 | 16.5 | 0.77 | 0.38–1.58 |
| Q3 | 185/201 | 21.4 | 1.03 | 0.70–1.51 | 76/40 | 23.0 | 0.78 | 0.33–1.86 |
| Q4 | 205/199 | 30.6 | 0.94 | 0.58–1.55 | 47/39 | 31.8 | 0.28 | 0.08–0.96 |
| P for linear trend | 0.68 | 0.78 | ||||||
| Protein (g) | ||||||||
| Q1 | 187/200 | 47.0 | 1.00 | 45/40 | 38.4 | 1.00 | ||
| Q2 | 176/200 | 66.1 | 0.90 | 0.64–1.27 | 55/40 | 60.7 | 1.05 | 0.51–2.16 |
| Q3 | 183/200 | 84.4 | 0.86 | 0.57–1.30 | 66/40 | 85.0 | 0.81 | 0.32–2.05 |
| Q4 | 174/200 | 115.4 | 0.57 | 0.32–1.01 | 59/39 | 122.0 | 0.58 | 0.16–2.10 |
| P for linear trend | 0.74 | 0.93 | ||||||
| Protein (% energy) | ||||||||
| Q1 | 272/200 | 11.9 | 1.00 | 67/40 | 10.7 | 1.00 | ||
| Q2 | 191/201 | 14.2 | 0.82 | 0.60–1.12 | 61/40 | 13.0 | 0.99 | 0.51–1.92 |
| Q3 | 140/199 | 15.6 | 0.65 | 0.47–0.91 | 59/40 | 15.2 | 0.95 | 0.47–1.88 |
| Q4 | 117/200 | 18.1 | 0.53 | 0.37–0.77 | 38/39 | 17.2 | 0.60 | 0.28–1.30 |
| P for linear trend | 0.003 | 0.59 | ||||||
a
Adjusted for age, sex, education, body mass index, family history, nonsteroidal anti-inflammatory drug use, physical activity, calcium, fiber, and total energy.