Table 4.
Multivariate adjusted models for fatty liver
| Dependent Trait | FL +covariates* | FL + covariates’ and obesity traits# | ||||||
|---|---|---|---|---|---|---|---|---|
| N | effect$ | 95% CI | p value | effect$ | 95% CI | p value | ||
| Glucose (mg/dL) | 2588 | 7.7 | [5.73–9.67] | <0.001 | 3.54 | [1.43–5.64] | 0.001 | |
| IFG | 2415 | 2.95 | [2.32 – 3.75] | <0.001 | 1.58 | [1.21 – 2.07] | <0.001 | |
| DM | 2588 | 2.98 | [2.12 – 4.21] | <0.001 | 1.64 | [1.11 – 2.41] | 0.012 | |
| log HOMA-IR | 2395 | 0.44 | [0.40 – 0.49] | <0.001 | 0.21 | [0.17 – 0.25] | <0.001 | |
| Insulin resistance | 2395 | 6.16 | [4.90 – 7.76] | <0.001 | 2.79 | [2.19–3.65] | <0.001 | |
| Adiponectin (mg/ml) | 854 | −3.17 | [−4.09 – −2.24] | <0.001 | −1.59 | −2.57 – −0.62] | 0.001 | |
| log Resistin (ng/ml) | 857 | 0.05 | [−0.02 – 0.12] | 0.147 | 0.00 | [−0.07 – 0.08 | 0.924 | |
| Dichotomous Fatty Liver | log TG (mg/dL) | 2588 | 0.41 | [0.35–0.46] | <0.001 | 0.22 | [0.17 – 0.28] | <0.001 |
| HDL (mg/dL) | 2588 | −7.08 | [−8.44 – −5.73] | <0.001 | −2.48 | [−3.89 – −1.06] | <0.001 | |
| SBP (mmHg) | 2589 | 4.61 | [3.10–6.12] | <0.001 | 1.38 | [−.22 – 2.97] | 0.091 | |
| DBP (mmHg) | 2587 | 2.88 | [1.96– 3.81] | <0.001 | 0.64 | [−0.34 – 1.61] | 0.2 | |
| HTN | 2586 | 2.73 | [2.16–3.44] | <0.001 | 1.52 | [1.17 – 1.97] | 0.002 | |
| MetS | 2587 | 5.22 | [4.15 – 6.57] | <0.001 | 1.95 | [1.48–2.56] | <0.001 | |
| BMI (kg/m2) | 2589 | 4.35 | [3.39–5.30] | <0.001 | ||||
| WC (cm) | 2589 | 4.14 | [3.41–4.86] | <0.001 | ||||
| SAT (cm3) | 2589 | 810 | [636–984 | <0.001 | ||||
| VAT (cm3) | 2589 | 989.2 | 865.5–1113.0] | <0.001 | ||||
| Dependent Trait | FL +covariates* | FL + covariates’ and obesity traits# | ||||||
|---|---|---|---|---|---|---|---|---|
| N | effect& | 95% CI | p value | effect | 95% CI | p value | ||
| Glucose (mg/dL) | 2588 | 2.91 | [2.17–3.65] | <0.001 | 1.36 | [0.56–2.15] | <0.001 | |
| IFG | 2415 | 1.43 | [1.30 – 1.56] | <0.001 | 1.10 | [1 – 1.22] | 0.047 | |
| DM | 2588 | 1.56 | [1.39 – 1.75] | <0.001 | 1.29 | [1.12 – 1.47] | <0.001 | |
| log HOMA-IR | 2395 | 0.17 | [0.16 – 0.19] | <0.001 | 0.08 | [0.07 –0.10] | <0.001 | |
| Insulin resistance | 2395 | 0.44 | [0.39–0.49] | <0.001 | 0.64 | [0.57–0.72] | <0.001 | |
| Adiponectin (mg/ml) | 854 | −1.26 | [−1.61 – −0.90] | <0.001 | −0.62 | [−1.00 – −0.24] | 0.001 | |
| log Resistm (ng/ml) | 857 | 0.03 | [0.00 – 0.06] | 0.032 | 0.01 | [−0.02 – 0.04] | 0.452 | |
| Continuous Fatty Liver | log TG (mg/dL) | 2588 | 0.14 | [0.12–0.16] | <0.001 | 0.07 | [0.05– 0.09] | <0.001 |
| HDL (mg/dL) | 2588 | −2.5 | [−3.01–−1.99] | <0.001 | −0.69 | [−1.23–−0.16] | 0.011 | |
| SBP (mmHg) | 2589 | 1.72 | [1.15 – 2.29] | <0.001 | 0.52 | [−0.08–1.12] | 0.092 | |
| DBP (mmHg) | 2587 | 1.09 | [.75 – 1.44] | <0.001 | 0.25 | [−0.12 – 0.61] | 0.19 | |
| HTN | 2586 | 1.52 | [1.28 – 1.64] | <0.001 | 1.22 | [1.10–1.35] | <0.001 | |
| MetS | 2587 | 1.96 | [1.79 – 2.17] | <0.001 | 1.27 | [1.12 – 1.41] | <0.001 | |
| BMI (kg/m2) | 2589 | 1.6 | [1.41–1.79] | <0.001 | ||||
| WC (cm) | 2589 | 1.62 | [1.42 – 1.81] | <0.001 | ||||
| SAT(cm3) | 2589 | 336.4 | [285.7–397.0] | <0.001 | ||||
| VAT (cm3) | 2589 | 365.5 | [335.1–395.9] | <0.001 | ||||
covariates= age, sex, alcoholic drinks per week, menopausal status, hormone replacement therapy, smoking
obesity traits= BMI, waist circumference, VAT
effect= the change in the continuous dependent trait or in the Odds Ratio of having the dependent trait in individuals with fatty liver compared to those without fatty liver.
effect= the change in the continuous dependent trait or in the Odds Ratio of having the dependent trait in individuals per standard deviation DECREASE in LPR.
FL: Fatty Liver
IFG: impaired fasting glucose
DM: diabetes mellitus
HOMA-IR: Homeostasis model assessment of insulin resistance
TG: triglycerides
HDL: high density lipoprotein
SEP: systolic blood pressure
DBP diastolic blood pressure
HTN: hypertension
MS: metabolic syndrome
BMI: body mass index
WC: waist circumference
SAT: subcutaneous adipose tissue
VAT: visceral adipose tissue