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. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Pigment Cell Melanoma Res. 2009 Jul 30;22(6):773–784. doi: 10.1111/j.1755-148X.2009.00616.x

Figure 1. Erbb3is expressed in MC precursors during embryonic development.

Figure 1

Lateral view of Erbb3 whole-mount in situ hybridization in wild-type (A, C) and MitfMi/Mi (B, D) embryos at E11.5. In both wild-type embryos and MitfMi/Mi mutants, Erbb3 expression is observed in the cranial ganglia and nerves, DRG and somites. In wild-type embryos (C), a population of Erbb3-expressing cells (black arrowheads) is detected in the vicinity of the otic vesicle, the location where Mbs are normally found. These Erbb3-expressing cells were absent in Mb-deficient mutants (D), indicating that these cells are Mbs. Labeled structures are otocyst (OT) trigeminal ganglia (V), dorsal root ganglia (DRG), otic vesicle (OV) and somites (SO).