Table 1.
Summary of domains and sites of posttranslational modifications involved in the regulation of rat Na+-K+-ATPase α1 surface expression
| Structural Determinant | Trigger/Signal Cascade | α1 Surface Expression | Ref. No |
|---|---|---|---|
| Tyrosine-based domain for AP-binding | ANG II/AT1/AP1 | Up | 17 |
| IVVY-255 | |||
| Tyrosine-based domain for AP-binding | Dopamine/DR1/AP2 | Down | 9, 13 |
| 537-YLEL | Hypoxia | ||
| Dileucine-based motif for AP-binding | None | Up | 44 |
| EPKHL-499L | |||
| Phosphorylation /S-18 | Dopamine | Down | 10 |
| Phosphorylation /S-18 | Hypoxia/PKC | Down | 14 |
| Phosphorylation /S-11 | PTH/PKC/ERK/CCV | Down | 24 |
| Ubiquitination/K-16/K-17/K-19/K-20 | Hypoxia/ubiquitination | Down | 15 |
| Proline-rich domain TPPPTTP-87 | Dopamine | Down | 49 |
ANG II, angiotensin II; AT1, Type 1 angiotensin II receptor; AP1 and AP2, clathrin adaptor protein 1 and 2; DR1, dopamine receptor 1; PKC, protein kinase C; PTH, parathyroid hormone; ERK, extracellular signal-regulated kinase; CCV, clathrin-coated vesicle.