Table 3.
Serum cytokine levels (pg/ml) in lean and obese Zucker rats and the effect of LSF
|
P Values (ANOVA) |
|||||
|---|---|---|---|---|---|
| Group | Lean | Obese | Obese + LSF | By genotype | By treatment |
| IL-1α | 784 ± 153 | 3,832 ± 284 | 632 ± 122 | P < 0.001 | P < 0.001 |
| MCP-1 | 469 ± 53 | 1,509 ± 280 | 866 ± 36.2 | P < 0.001 | P < 0.05 |
| IL-6 | 6,958 ± 540 | 24,508 ± 5,955 | 2,916 ± 492 | P < 0.01 | P < 0.001 |
| IL-12p70 | 322 ± 45 | 1,367 ± 140 | 288 ± 68 | P < 0.0001 | P < 0.001 |
| IFNγ | 1,272 ± 216 | 6,243 ± 671 | 763 ± 162 | P < 0.001 | P < 0.001 |
All data represent the mean ± SE from 3 independent experiments, and P values indicate that values are statistically significantly different (P < 0.001-0.05) when compared with lean and saline-treated obese rats.