Fig. 4.
Renal dopamine D1 receptor activation produces diuresis (urine flow) in adult and old rats. Urine flow in response to D1 receptor agonist SKF-38393 (1 μg·kg−1·min−1 iv) was measured in anesthetized rats (details in methods). C represents average of 2 30-min control periods where saline only was infused. D represents 30-min drug infusion period where SKF-38393 in saline was infused. Results are means ± SE (n = 6 adult and 8 old rats). **Significantly different from C in adult rats at P < 0.01. #Significantly different from C in old rats at P < 0.05. Statistical significance was achieved using paired t-test.