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Renal dopamine D1 receptor activation produces natriuresis (UNaV) in adult but not in old rats. UNaV in response to D1 receptor agonist SKF-38393 (1 μg·kg−1·min−1 iv) was determined in anesthetized rats (details in methods). C and D as defined in Fig. 4. Results are means ± SE (n = 6 adult and 10 old rats). *Significantly different from C in adult rats at P < 0.05 (paired t-test).
