Fig. 1.

Echocardiographic measurements and heart weights. A: heart weight-to-body weight ratios were greater in wild-type (WT) mice and mice with cardiac selective deletion of the insulin receptor (CIRKO) that were exposed to 14 days of transverse aortic constriction (TAC) vs. a sham operation (sham). *P < 0.05, sham vs. TAC; **P < 0.05, CIRKO vs. similarly treated WT. B: left ventricular (LV) internal diastolic dimension in sham and TAC mice was similar between groups. C: fractional shortening in sham and TAC mice was similar between groups. The no. of mice/group = 8 (WT-sham and WT-TAC) and 6 (CIRKO-sham and CIRKO-TAC).