Fig. 3.

Elevation of MAP with phenylephrine (PE) does not attenuate the CBF responses. A: time course of the systolic blood pressure elevation by tail-cuff plethysmography induced by infusion of PE (3 μg·kg⁻¹·min⁻¹) for 14 days. SAP, systolic arterial pressure. *P < 0.05 from saline; n = 5/group. B: increases in MAP induced by PE in anesthetized mice in which CBF was monitored. C–E: despite the MAP increase, PE does not attenuate the increase in CBF induced by whisker stimulation, ACh, or adenosine. P > 0.05 from vehicle; n = 5/group.