Table 9.

Effect of rosuvastatin coadministration with warfarin, digoxin, and an oral contraceptive

Rosuvastatin dosage regimen	Coadministered drug
	Name and dose	Change in AUC	Change in Cmax
40 mg daily for 10 days	Warfarin 25 mg, single dose	R-Warfarin ↑ 4% S-Warfarin ↑ 6%	R-Warfarin ↓ 1% S-Warfarin 0%
40 mg daily for 12 days	Digoxin 0.5 mg, single dose	↑ 4%	↑ 4%
40 mg daily for 28 days	Oral contraceptive (EE 0.035 mg and NG 0.180, 0.215, and 0.250 mg) daily for 21 days	EE ↑ 26% NG ↑ 34%	EE ↑ 25% NG ↑ 23%

Abbreviations: AUC, area under the plasma concentration-time curve; C_max, peak plasma concentration; EE, ethinyl estradiol; NG, norgestrel; R-warfarin and S-warfarin, referring to the stereoisomers.