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Concerted action of MAPK pathways and proteasome function on IL-8 mRNA stability in CF cells. IL-8 mRNA stabilization in CF lung epithelial cells as well as CF bronchial epithelial cells is promoted by constitutive activation of p38 and ERK1/2 pathways. However, inhibition of JNK-2 as well as the proteasome has no effect on IL-8 mRNA stability in these CF cells.
