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Some Molecular Regulators of Apoptosis Relevant to Neurodegeneration and Potential Drug Targeting for Neuroprotection.
| Bcl-2 Family | Caspase Family | IAP Family | Tumor Suppressor | |
| Anti-apoptotic proteins | Pro-apoptotic proteins | |||
| Bcl-2 | Bax | Apoptosis “initiators”: caspase-2, 8, 9, 10 | NAIP | p53 |
| Bcl-xL | Bak1 | Apollon | p63 | |
| Mcl-1 | Bcl-xS | Survivin | p73 | |
| Boo/Diva | Bad | Apoptosis “executioners”: caspase-2, 3, 6, 7 | IAP1 | |
| Bid | IAP2 | |||
| Bik | XIAP | |||
| Bim | Cytokine processors: caspase-1, 4, 5, 11, 12, 14 | |||
| Noxa | ||||
| Puma | ||||
