Table 3.
Mutant Genes Linked to Familial PD.
| Locus | Inheritance | Gene | Protein Name/ Function |
|---|---|---|---|
| PARK1/4q21 | autosomal dominant | α-syn | α-Syn/presynaptic maintenance? |
| PARK2/6q25.2-27 | autosomal recessive | parkin | Parkin/ubiquitin E3 ligase |
| PARK3/2p13 | autosomal dominant | ? | ? |
| PARK4/4p15 | autosomal dominant | α-syn | α-Syn/presynaptic maintenance? |
| PARK5/4p14 | autosomal dominant | UCHL1 | UCHL1/polyubiquitin hydrolase |
| PARK6/1p36 | autosomal recessive | PINK1 | PTEN-induced putative kinase-1/mitochondrial protein kinase |
| PARK7/1p36.33-36-12 | autosomal recessive | DJ-1 | DJ-1/mitochondrial antioxidant, chaperone |
| PARK8/12q12 | autosomal dominant | LRRK2 | Dardarin/multifunctional kinase/GTPase |
| PARK9/1p36 | autosomal recessive | ATP13A2 | Lysosomal type 5 P-ATPase |
| PARK10/1p32 | ? | ? | |
| PARK11/2q36-37 | autosomal dominant | GIGYF2? | Grb10-interacting GYP protein 2, modulates tyrosine kinase receptor signaling, including IGF-1 |
| PARK12/Xq21-q25 | X-linked | ? | ? |
| PARK13/2p12 | autosomal recessive susceptibility factor | Omi/HtrA2 | Omi/HtrA2, mitochondrial serine peptidase, inhibitor of IAPs |
| PARK14/22q13.1 | autosomal recessive | PLA2G6 | Phospholipase A2 group VI |
| PARK15/22q12-q13 | autosomal recessive | FBXO7 | F-box protein 7 |