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A) Representative images from immunostains of colon tubular adenomas is shown. In contrast to normal colonic crypts, where Trask phosphorylation is restricted to mitotic cells, in adenomas there is abundant Trask phosphorylation in many clusters and foci of tumor cells. There is also abundant tumor cell luminal shedding. B) The frequent luminal shedding in adnomas is non-mitotic as confirmed by the absence of phospho-Histone H3 staining.
